^what Nyambo said.
Couple of thoughts:
- For Cubase, I had a similar problem. Click on the In1/In2 button above each fader the mixer and switch it around. That normally helps.
- The delay is caused by buffer lag. In Cubase, select Devices > Device setup > VST Multitrack. Play a little with the settings. Sorry I can't give exact, it depends on your system, but it should sort it.