REASON 4 has the NEW REGROOVE capability, that kinda gives you all the benefits of quantizing and even a nice swing to the beat...i havent been able to make a beat since i touched REASON 4 without using this function, the QUANTIZE & REGROOVE feature make the beat sound much more LIVER than say, just a layering of samples...
thats why in a beat battle, with limited time to cook i feel confident enough to walk into the challenge with an 8 bar loop...with the proper REGROOVE combination, you can have it sounding nice with as much variation as you would like as the loops are extended!